Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis.

Article Details

Citation

Carroll AR, Suraweera L, King G, Rali T, Quinn RJ

Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis.

J Nat Prod. 2009 Sep;72(9):1699-701. doi: 10.1021/np900246t.

PubMed ID
19681589 [ View in PubMed
]
Abstract

Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative configurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC(50) values of 22.0 microM.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
StaurosporineMAP kinase-activated protein kinase 2IC 50 (nM)150N/AN/ADetails