Effect of neramexane on ethanol dependence and reinforcement.
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Kotlinska J, Biala G, Rafalski P, Bochenski M, Danysz W
Effect of neramexane on ethanol dependence and reinforcement.
Eur J Pharmacol. 2004 Oct 25;503(1-3):95-8.
- PubMed ID
- 15496302 [ View in PubMed]
- Abstract
It has been suggested that drugs modulating the glutamate/N-methyl-D-aspartate (NMDA) receptor system may be useful in the treatment of alcohol dependence. The effect of neramexane, a low-to-moderate affinity uncompetitive NMDA receptor antagonist, was examined on the development and expression of ethanol dependence (withdrawal-associated audiogenic seizures) and ethanol-induced conditioned place preference. Neramexane hydrochloride (3.5 mg/kg and higher) inhibited both the development and expression of ethanol dependence. Neramexane hydrochloride also inhibited the acquisition (1.75 mg/kg and higher) and expression (3.5 mg/kg and higher) of ethanol-induced place preference. Our data support therapeutic potential of neramexane as a treatment for alcohol abuse.
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