The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.

Article Details

Citation

Copy to clipboard

Levin JI, Du MT, DiJoseph JF, Killar LM, Sung A, Walter T, Sharr MA, Roth CE, Moy FJ, Powers R, Jin G, Cowling R, Skotnicki JS

The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):235-8.

PubMed ID

11206467 [ View in PubMed

]

Abstract

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
WAY-151693	Collagenase 3	IC 50 (nM)	8	N/A	N/A	Details