5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.

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Ryu CK, Kang HY, Lee SK, Nam KA, Hong CY, Ko WG, Lee BH

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.

Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.

PubMed ID
10743948 [ View in PubMed
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Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
OlomoucineCyclin-dependent kinase 2IC 50 (nM)7N/AN/ADetails
SeliciclibCyclin-dependent kinase 2IC 50 (nM)0.6N/AN/ADetails