Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.

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Ahmed S, James K, Owen CP, Patel CK, Patel MB

Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3001-5.

PubMed ID

11714597 [ View in PubMed

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Abstract

Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Irosustat	Steryl-sulfatase	IC 50 (nM)	8	N/A	N/A	Details