Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Article Details

Citation

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22.

PubMed ID
16797988 [ View in PubMed
]
Abstract

The synthesis of a red-shifted cy3B-GM ligand and its evaluation as a fluorescence polarization probe for Hsp90 is presented.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-YlamineHeat shock protein HSP 90-alphaEC 50 (nM)1200N/AN/ADetails