PI3Kdelta and PI3Kgamma as targets for autoimmune and inflammatory diseases.

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Cushing TD, Metz DP, Whittington DA, McGee LR

PI3Kdelta and PI3Kgamma as targets for autoimmune and inflammatory diseases.

J Med Chem. 2012 Oct 25;55(20):8559-81. doi: 10.1021/jm300847w. Epub 2012 Sep 13.

PubMed ID

22924688 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC 50 (nM)	180	N/A	N/A	Details
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IC 50 (nM)	17000	N/A	N/A	Details
LY-294002	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IC 50 (nM)	6600	N/A	N/A	Details
Wortmannin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IC 50 (nM)	1	N/A	N/A	Details
Wortmannin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IC 50 (nM)	5	N/A	N/A	Details