Structure-activity relationship studies of flavopiridol analogues.

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Murthi KK, Dubay M, McClure C, Brizuela L, Boisclair MD, Worland PJ, Mansuri MM, Pal K

Structure-activity relationship studies of flavopiridol analogues.

Bioorg Med Chem Lett. 2000 May 15;10(10):1037-41.

PubMed ID

10843211 [ View in PubMed

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Abstract

Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Alvocidib	Cyclin-dependent kinase 1	IC 50 (nM)	200	N/A	N/A	Details