Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

Article Details

Citation

Copy to clipboard

Rosauer KG, Ogawa AK, Willoughby CA, Ellsworth KP, Geissler WM, Myers RW, Deng Q, Chapman KT, Harris G, Moller DE

Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4385-8.

PubMed ID

14643331 [ View in PubMed

]

Abstract

The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate	Glycogen phosphorylase, liver form	IC 50 (nM)	45	N/A	N/A	Details