A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.

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Chambers RJ, Abrams K, Castleberry TA, Cheng JB, Fisher DA, Kamath AV, Marfat A, Nettleton DO, Pillar JD, Salter ED, Sheils AL, Shirley JT, Turner CR, Umland JP, Lam KT

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.

Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. Epub 2005 Nov 2.

PubMed ID

16263279 [ View in PubMed

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Abstract

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
(R)-Rolipram	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	IC 50 (nM)	625	N/A	N/A	Details
(R)-Rolipram	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	IC 50 (nM)	34	N/A	N/A	Details
(R)-Rolipram	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	IC 50 (nM)	33	N/A	N/A	Details
(R)-Rolipram	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	IC 50 (nM)	41	N/A	N/A	Details