Synthesis and biological evaluation of novel EG5 inhibitors.

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Sarli V, Huemmer S, Sunder-Plassmann N, Mayer TU, Giannis A

Synthesis and biological evaluation of novel EG5 inhibitors.

Chembiochem. 2005 Nov;6(11):2005-13.

PubMed ID

16216042 [ View in PubMed

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Abstract

Human Eg5 is a mitotic kinesin that is essential for bipolar spindle formation and maintenance during mitosis. Recently, the discovery of compounds that inhibit Eg5 and cause mitotic arrest has attracted great interest, due to their potential use as the next generation of antimitotics. Here, we present the synthesis and biological investigation of 3,4-dihydrophenylquinazoline-2(1H)-thiones as selective and potent Eg5 inhibitors.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Monastrol	Kinesin-like protein KIF11	IC 50 (nM)	2.07E+04	6.8	25	Details