Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.

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Sashidhara KV, Avula SR, Sharma K, Palnati GR, Bathula SR

Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.

Eur J Med Chem. 2013 Feb;60:120-7. doi: 10.1016/j.ejmech.2012.11.044. Epub 2012 Dec 8.

PubMed ID

23287057 [ View in PubMed

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Abstract

Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Monastrol	Kinesin-like protein KIF11	IC 50 (nM)	14000	N/A	N/A	Details