Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

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Najda-Bernatowicz A, Lebska M, Orzeszko A, Kopanska K, Krzywinska E, Muszynska G, Bretner M

Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

Bioorg Med Chem. 2009 Feb 15;17(4):1573-8. doi: 10.1016/j.bmc.2008.12.071. Epub 2009 Jan 7.

PubMed ID

19168362 [ View in PubMed

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Abstract

New derivatives of 4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole (TBBt), 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi), and N-substituted tetrabromophthalimides were synthesized and their effect on the activity of human protein kinase CK2 was examined. The most active were derivatives with N-hydroxypropyl substituents (IC(50) in 0.32-0.54 microM range) whereas derivatives of phthalimide were almost ineffective.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Tetrabromo-2-Benzotriazole	Casein kinase II subunit alpha	IC 50 (nM)	500	N/A	N/A	Details