Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.

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Stewart KD, Loren S, Frey L, Otis E, Klinghofer V, Hulkower KI

Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.

Bioorg Med Chem Lett. 1998 Mar 3;8(5):529-34.

PubMed ID

9871612 [ View in PubMed

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Abstract

Using a combination of computational and combinatorial chemistry methodologies, a phenothiazine compound was discovered that is a selective inhibitor of cyclooxygenase-2 and serves as a lead compound for a potentially novel series of anti-inflammatory compounds.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Nimesulide	Prostaglandin G/H synthase 2	IC 50 (nM)	15	N/A	N/A	Details