1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.

Article Details

Citation

Copy to clipboard

Barber CG, Blakemore DC, Chiva JY, Eastwood RL, Middleton DS, Paradowski KA

1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1499-503. doi: 10.1016/j.bmcl.2009.01.008. Epub 2009 Jan 10.

PubMed ID

19185490 [ View in PubMed

]

Abstract

Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Maraviroc	C-C chemokine receptor type 5	IC 50 (nM)	0.2	N/A	N/A	Details