2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

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Giardina GA, Sarau HM, Farina C, Medhurst AD, Grugni M, Foley JJ, Raveglia LF, Schmidt DB, Rigolio R, Vassallo M, Vecchietti V, Hay DW

2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

J Med Chem. 1996 Jun 7;39(12):2281-4.

PubMed ID

8691422 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Osanetant	Neuromedin-K receptor	Ki (nM)	1.2	N/A	N/A	Details
Osanetant	Neuromedin-K receptor	IC 50 (nM)	320	N/A	N/A	Details
Talnetant	Neuromedin-K receptor	Ki (nM)	1	N/A	N/A	Details