Synthesis and biological activities of NB-506 analogues modified at the glucose group.

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Ohkubo M, Nishimura T, Kawamoto H, Nakano M, Honma T, Yoshinari T, Arakawa H, Suda H, Morishima H, Nishimura S

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22.

PubMed ID

10743939 [ View in PubMed

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Abstract

A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Edotecarin	DNA topoisomerase 1	EC 50 (nM)	51	N/A	N/A	Details
Edotecarin	DNA topoisomerase 1	EC 50 (nM)	300	N/A	N/A	Details