Synthesis and biological activities of NB-506 analogues modified at the glucose group.
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Ohkubo M, Nishimura T, Kawamoto H, Nakano M, Honma T, Yoshinari T, Arakawa H, Suda H, Morishima H, Nishimura S
Synthesis and biological activities of NB-506 analogues modified at the glucose group.
Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22.
- PubMed ID
- 10743939 [ View in PubMed]
- Abstract
A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Edotecarin DNA topoisomerase 1 EC 50 (nM) 51 N/A N/A Details Edotecarin DNA topoisomerase 1 EC 50 (nM) 300 N/A N/A Details