Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

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Mohler ML, Bohl CE, Jones A, Coss CC, Narayanan R, He Y, Hwang DJ, Dalton JT, Miller DD

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

J Med Chem. 2009 Jun 25;52(12):3597-617. doi: 10.1021/jm900280m.

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19432422 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE	Androgen receptor	Ki (nM)	0.3	N/A	N/A	Details
Andarine	Androgen receptor	Ki (nM)	4	N/A	N/A	Details
BMS-564929	Androgen receptor	Ki (nM)	2.1	N/A	N/A	Details
LGD-2226	Androgen receptor	Ki (nM)	1.5	N/A	N/A	Details
LGD2941	Androgen receptor	Ki (nM)	1.5	N/A	N/A	Details
S-23	Androgen receptor	Ki (nM)	1.7	N/A	N/A	Details
S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE	Androgen receptor	Ki (nM)	6.1	N/A	N/A	Details