3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.

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Kanyonyo M, Govaerts SJ, Hermans E, Poupaert JH, Lambert DM

3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2233-6.

PubMed ID

10465552 [ View in PubMed

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Abstract

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rimonabant	Cannabinoid receptor 1	Ki (nM)	8.9	N/A	N/A	Details