Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.

Article Details

Citation

Srivastava BK, Soni R, Patel JZ, Joharapurkar A, Sadhwani N, Kshirsagar S, Mishra B, Takale V, Gupta S, Pandya P, Kapadnis P, Solanki M, Patel H, Mitra P, Jain MR, Patel PR

Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.

Bioorg Med Chem Lett. 2009 May 1;19(9):2546-50. doi: 10.1016/j.bmcl.2009.03.046. Epub 2009 Mar 17.

PubMed ID
19328683 [ View in PubMed
]
Abstract

A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
RimonabantCannabinoid receptor 1EC 50 (nM)240N/AN/ADetails