Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.
Article Details
- CitationCopy to clipboard
Foloppe N, Benwell K, Brooks TD, Kennett G, Knight AR, Misra A, Monck NJ
Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.
Bioorg Med Chem Lett. 2009 Aug 1;19(15):4183-90. doi: 10.1016/j.bmcl.2009.05.114. Epub 2009 Jun 2.
- PubMed ID
- 19520572 [ View in PubMed]
- Abstract
Ligand-based virtual screening with a 3D pharmacophore led to the discovery of 30 novel, diverse and drug-like ligands of the human cannabinoid receptor 1 (hCB(1)). The pharmacophore was validated with a hit rate of 16%, binding selectivity versus hCB(2), and expected functional profiles. The discovered compounds provide new tools for exploring cannabinoid pharmacology.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Rimonabant Cannabinoid receptor 1 EC 50 (nM) 4 N/A N/A Details Rimonabant Cannabinoid receptor 1 Ki (nM) 1.9 N/A N/A Details