Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

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Kitajima M, Iwai M, Kikura-Hanajiri R, Goda Y, Iida M, Yabushita H, Takayama H

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. doi: 10.1016/j.bmcl.2011.02.036. Epub 2011 Feb 13.

PubMed ID

21376588 [ View in PubMed

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Abstract

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rimonabant	Cannabinoid receptor 1	IC 50 (nM)	4	N/A	N/A	Details