Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.

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Killday KB, Yarwood D, Sills MA, Murphy PT, Hooper JN, Wright AE

Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.

J Nat Prod. 2001 Apr;64(4):525-6.

PubMed ID

11325241 [ View in PubMed

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Abstract

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Seliciclib	Cyclin-dependent kinase 1	IC 50 (nM)	200	N/A	N/A	Details