Pyrimidinylmethylphenyl glucoside as novel C-aryl glucoside SGLT2 inhibitors.

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Lee J, Kim JY, Choi J, Lee SH, Kim J, Lee J

Pyrimidinylmethylphenyl glucoside as novel C-aryl glucoside SGLT2 inhibitors.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):7046-9. doi: 10.1016/j.bmcl.2010.09.103. Epub 2010 Sep 29.

PubMed ID

20952196 [ View in PubMed

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Abstract

Novel C-aryl glucoside SGLT2 inhibitors containing pyrimidine motif were designed and synthesized for biological evaluation. Among the compounds assayed, pyrimidine containing methylthio moiety 11 g demonstrated the best in vitro inhibitory activity against SGLT2 in this series to date (IC(50)=10.7 nM).

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Dapagliflozin	Sodium/glucose cotransporter 2	IC 50 (nM)	0.49	N/A	N/A	Details