Characteristics of histamine H1 receptors on HeLa cells.

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Arias-Montano JA, Young JM

Characteristics of histamine H1 receptors on HeLa cells.

Eur J Pharmacol. 1993 May 15;245(3):291-5.

PubMed ID

8335064 [ View in PubMed

]

Abstract

The affinities of antagonists at histamine H1 receptors on HeLa cells have been determined from inhibition of histamine-induced inositol phosphate formation in intact and from inhibition of [3H]mepyramine binding to HeLa cell membranes. The dissociation constants of mepyramine and (+)-chlorpheniramine were similar to values for binding to H1 receptors in other mammalian tissues, but much lower than the values reported in an earlier study with [3H]mepyramine and HeLa cell membranes. Evidence is presented that under conditions employed in the earlier study the binding of [3H]mepyramine is largely to secondary, non-H1 receptor sites.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Mepyramine	Histamine H1 receptor	Ki (nM)	4.7	N/A	N/A	Details