Characteristics of histamine H1 receptors on HeLa cells.
Article Details
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Arias-Montano JA, Young JM
Characteristics of histamine H1 receptors on HeLa cells.
Eur J Pharmacol. 1993 May 15;245(3):291-5.
- PubMed ID
- 8335064 [ View in PubMed]
- Abstract
The affinities of antagonists at histamine H1 receptors on HeLa cells have been determined from inhibition of histamine-induced inositol phosphate formation in intact and from inhibition of [3H]mepyramine binding to HeLa cell membranes. The dissociation constants of mepyramine and (+)-chlorpheniramine were similar to values for binding to H1 receptors in other mammalian tissues, but much lower than the values reported in an earlier study with [3H]mepyramine and HeLa cell membranes. Evidence is presented that under conditions employed in the earlier study the binding of [3H]mepyramine is largely to secondary, non-H1 receptor sites.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Mepyramine Histamine H1 receptor Ki (nM) 4.7 N/A N/A Details