Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.

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Marsault E, Peterson ML

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.

J Med Chem. 2011 Apr 14;54(7):1961-2004. doi: 10.1021/jm1012374. Epub 2011 Mar 7.

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21381769 [ View in PubMed

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
(13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE	Cyclin-dependent kinase 2	IC 50 (nM)	3.4	N/A	N/A	Details
6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE	Cyclin-dependent kinase 2	IC 50 (nM)	140	N/A	N/A	Details