3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
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Lee J, Park T, Jeong S, Kim KH, Hong C
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15.
- PubMed ID
- 17178224 [ View in PubMed]
- Abstract
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE Cyclin-dependent kinase 2 IC 50 (nM) 87 N/A N/A Details