3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Article Details

Citation

Lee J, Park T, Jeong S, Kim KH, Hong C

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15.

PubMed ID
17178224 [ View in PubMed
]
Abstract

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONECyclin-dependent kinase 2IC 50 (nM)87N/AN/ADetails