The discovery of equipotent PPARalpha/gamma dual activators.

Article Details

Citation

Martres P, Faucher N, Laroze A, Pineau O, Fouchet MH, Potvain F, Grillot D, Beneton V

The discovery of equipotent PPARalpha/gamma dual activators.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6251-4. doi: 10.1016/j.bmcl.2008.09.094. Epub 2008 Oct 1.

PubMed ID
18947994 [ View in PubMed
]
Abstract

We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
GW-590735Peroxisome proliferator-activated receptor alphaEC 50 (nM)4N/AN/ADetails