Discovery and development of aurora kinase inhibitors as anticancer agents.

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Pollard JR, Mortimore M

Discovery and development of aurora kinase inhibitors as anticancer agents.

J Med Chem. 2009 May 14;52(9):2629-51. doi: 10.1021/jm8012129.

PubMed ID

19320489 [ View in PubMed

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea	Aurora kinase A	IC 50 (nM)	22	N/A	N/A	Details