Quinazolines as cyclin dependent kinase inhibitors.

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Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP

Quinazolines as cyclin dependent kinase inhibitors.

Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60.

PubMed ID

11354366 [ View in PubMed

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Abstract

Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE	Cyclin-dependent kinase 2	IC 50 (nM)	600	7.6	22	Details