Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.
Article Details
- CitationCopy to clipboard
Altmann E, Cowan-Jacob SW, Missbach M
Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.
J Med Chem. 2004 Nov 18;47(24):5833-6.
- PubMed ID
- 15537340 [ View in PubMed]
- Abstract
Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile Cathepsin K IC 50 (nM) 6 N/A N/A Details 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE Cathepsin K IC 50 (nM) 3.5 N/A N/A Details