Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
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Porter J, Lumb S, Lecomte F, Reuberson J, Foley A, Calmiano M, le Riche K, Edwards H, Delgado J, Franklin RJ, Gascon-Simorte JM, Maloney A, Meier C, Batchelor M
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. doi: 10.1016/j.bmcl.2008.11.062. Epub 2008 Nov 21.
- PubMed ID
- 19059779 [ View in PubMed]
- Abstract
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol Hepatocyte growth factor receptor IC 50 (nM) 900 N/A N/A Details