Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

Article Details

Citation

Copy to clipboard

Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1397-401. Epub 2005 Dec 5.

PubMed ID

16337120 [ View in PubMed

]

Abstract

The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE	Mitogen-activated protein kinase 10	IC 50 (nM)	235	N/A	N/A	Details