A modular approach to trim cellular targets in anticancer drug discovery.

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Rios-Luci C, Dominguez-Kelly R, Leon LG, Diaz-Rodriguez E, Freire R, Pandiella A, Cikotiene I, Padron JM

A modular approach to trim cellular targets in anticancer drug discovery.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6641-5. doi: 10.1016/j.bmcl.2011.09.069. Epub 2011 Sep 22.

PubMed ID

21986585 [ View in PubMed

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Abstract

A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE	Cyclin-dependent kinase 2	Ki (nM)	1300	N/A	N/A	Details