Selective inhibition of low affinity IgE receptor (CD23) processing.

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Bailey S, Bolognese B, Buckle DR, Faller A, Jackson S, Louis-Flamberg P, McCord M, Mayer RJ, Marshall LA, Smith DG

Selective inhibition of low affinity IgE receptor (CD23) processing.

Bioorg Med Chem Lett. 1998 Jan 6;8(1):29-34.

PubMed ID

9871623 [ View in PubMed

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Abstract

A series of hydroxamic acids related to the non-selective matrix metalloproteinase inhibitor Batimastat has been prepared, some members of which are potent inhibitors of the processing of the low affinity IgE receptor (CD 23). Increased activity is obtained by appropriate substitution at the alpha-position, whilst selectivity is gained by use of a P1' benzyl group in conjunction with a C-terminal primary amide.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID	Interstitial collagenase	IC 50 (nM)	60	N/A	N/A	Details