Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Article Details

Citation

Kim SH, Pudzianowski AT, Leavitt KJ, Barbosa J, McDonnell PA, Metzler WJ, Rankin BM, Liu R, Vaccaro W, Pitts W

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6.

PubMed ID
15686921 [ View in PubMed
]
Abstract

Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
CTS-1027Collagenase 3Ki (nM)0.52N/AN/ADetails