Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Article Details
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Kim SH, Pudzianowski AT, Leavitt KJ, Barbosa J, McDonnell PA, Metzler WJ, Rankin BM, Liu R, Vaccaro W, Pitts W
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6.
- PubMed ID
- 15686921 [ View in PubMed]
- Abstract
Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) CTS-1027 Collagenase 3 Ki (nM) 0.52 N/A N/A Details