Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.

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He W, Hanney B, Myers MR, Condon S, Becker MR, Spada AP, Burns C, Brown K, Colussi D, Chu V

Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.

Bioorg Med Chem Lett. 2002 Mar 25;12(6):919-22.

PubMed ID

11958994 [ View in PubMed

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Abstract

Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE	Coagulation factor X	Ki (nM)	1	N/A	N/A	Details