Pertactin antigens extracted from Bordetella pertussis and Bordetella bronchiseptica differ in the isoelectric point.

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Pagliaccia C, Manetti R, Rappuoli R

Pertactin antigens extracted from Bordetella pertussis and Bordetella bronchiseptica differ in the isoelectric point.

Arch Microbiol. 1997 Nov;168(5):437-40.

PubMed ID
9325433 [ View in PubMed
]
Abstract

Pertactin, which is a membrane-associated antigen of Bordetella pertussis and which is present in many acellular vaccines against whooping cough, has been reported to be similar to the homologous protein in Bordetella bronchiseptica. By running parallel experiments using proteins derived from the two species, we show that the isoelectric point of pertactin from B. pertussis is lower than reported and clearly distinguishable from the homologous protein of B. bronchiseptica.

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