From the journal archives: cyclopropane: induction and recovery with a bang!

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Bokoch MP, Gelb AW

From the journal archives: cyclopropane: induction and recovery with a bang!

Can J Anaesth. 2014 Aug;61(8):763-6. doi: 10.1007/s12630-014-0109-x. Epub 2014 Jan 14.

PubMed ID
24421247 [ View in PubMed
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Abstract

PURPOSE: To review the history of the early development of cyclopropane PRINCIPAL FINDINGS: Cyclopropane was initially investigated because it was thought to be the toxic element in ethylene. Instead, it turned out to be an excellent anesthetic with very rapid onset and recovery while maintaining stable hemodynamics. Its use was ultimately limited because it was highly explosive. Development required collaboration among laboratory scientists and clinicians in Toronto, Canada, clinicians in Madison, USA, and industry in both countries. CONCLUSIONS: The phenomenal success of cyclopropane in over 40 years of clinical use resulted from a lucky, but incorrect, hypothesis that it was a toxic contaminant.

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