Lutetium-labelled peptides for therapy of neuroendocrine tumours.
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Kam BL, Teunissen JJ, Krenning EP, de Herder WW, Khan S, van Vliet EI, Kwekkeboom DJ
Lutetium-labelled peptides for therapy of neuroendocrine tumours.
Eur J Nucl Med Mol Imaging. 2012 Feb;39 Suppl 1:S103-12. doi: 10.1007/s00259-011-2039-y.
- PubMed ID
- 22388631 [ View in PubMed]
- Abstract
Treatment with radiolabelled somatostatin analogues is a promising new tool in the management of patients with inoperable or metastasized neuroendocrine tumours. Symptomatic improvement may occur with (177)Lu-labelled somatostatin analogues that have been used for peptide receptor radionuclide therapy (PRRT). The results obtained with (177)Lu-[DOTA(0),Tyr(3)]octreotate (DOTATATE) are very encouraging in terms of tumour regression. Dosimetry studies with (177)Lu-DOTATATE as well as the limited side effects with additional cycles of (177)Lu-DOTATATE suggest that more cycles of (177)Lu-DOTATATE can be safely given. Also, if kidney-protective agents are used, the side effects of this therapy are few and mild and less than those from the use of (90)Y-[DOTA(0),Tyr(3)]octreotide (DOTATOC). Besides objective tumour responses, the median progression-free survival is more than 40 months. The patients' self-assessed quality of life increases significantly after treatment with (177)Lu-DOTATATE. Lastly, compared to historical controls, there is a benefit in overall survival of several years from the time of diagnosis in patients treated with (177)Lu-DOTATATE. These findings compare favourably with the limited number of alternative therapeutic approaches. If more widespread use of PRRT can be guaranteed, such therapy may well become the therapy of first choice in patients with metastasized or inoperable neuroendocrine tumours.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Lutetium Lu 177 dotatate Somatostatin receptor type 1 Protein Humans YesAgonistDetails Lutetium Lu 177 dotatate Somatostatin receptor type 2 Protein Humans YesAgonistDetails Lutetium Lu 177 dotatate Somatostatin receptor type 3 Protein Humans YesAgonistDetails Lutetium Lu 177 dotatate Somatostatin receptor type 4 Protein Humans YesAgonistDetails Lutetium Lu 177 dotatate Somatostatin receptor type 5 Protein Humans YesAgonistDetails