Single oral dose kinetics of zotepine and its relationship to prolactin response and side effects.

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Tanaka O, Kondo T, Otani K, Yasui N, Tokinaga N, Kaneko S

Single oral dose kinetics of zotepine and its relationship to prolactin response and side effects.

Ther Drug Monit. 1998 Feb;20(1):117-9.

PubMed ID
9485566 [ View in PubMed
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Abstract

The authors investigated the single oral dose kinetics of zotepine and its relationship with prolactin response and side effects in 14 healthy male volunteers. Each subject took a single oral 25-mg dose of zotepine, and plasma concentrations of zotepine, prolactin, and their side effects were monitored up to 36 hours after dosing. The means +/- SD of the time of maximal plasma concentration (tmax), the apparent oral clearance, the apparent volume of distribution, and the elimination half-life (t1/2) were 3.8 +/- 1.2 hours, 4.6 +/- 4.2 1/h.kg, 109.0 +/- 59.0 1/kg, and 21.0 +/- 8.9 hours, respectively. The change in prolactin concentrations and side effect scores were parallel with that of drug concentrations, although no significant correlation was found between these three parameters at any time-point. The current results clearly indicate that the tmax and t1/2 of zotepine are much longer than those previously reported, which are reflected in the changes in prolactin concentrations and side effect scores.

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