Profile of delamanid for the treatment of multidrug-resistant tuberculosis.
Article Details
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Szumowski JD, Lynch JB
Profile of delamanid for the treatment of multidrug-resistant tuberculosis.
Drug Des Devel Ther. 2015 Jan 29;9:677-82. doi: 10.2147/DDDT.S60923. eCollection 2015.
- PubMed ID
- 25678771 [ View in PubMed]
- Abstract
New approaches to the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) are badly needed. Not only is the success rate of current treatment regimens suboptimal but existing regimens require multiple drugs and lengthy courses and may lead to significant toxicities. The treatment landscape is beginning to shift, however, with the recent approvals of the new TB drugs bedaquiline and delamanid. Delamanid, a dihydro-imidazooxazole, has been shown to have excellent activity against Mycobacterium tuberculosis in both in vitro and in murine TB models. It has also recently been reported to improve rates of sputum culture conversion in patients with multidrug-resistant TB when added to an optimized background regimen. Although generally well tolerated, delamanid has been associated with QT prolongation, which may be of particular clinical concern when paired with other TB drugs that may also have this effect, most notably the fluoroquinolones. Ongoing studies will help to clarify delamanid's role in the treatment of drug-resistant TB.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Delamanid Deazaflavin-dependent nitroreductase Protein Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) NoSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareDelamanidMidostaurin The metabolism of Delamanid can be decreased when combined with Midostaurin. DelamanidDelavirdine The metabolism of Delamanid can be decreased when combined with Delavirdine. DelamanidNefazodone The metabolism of Delamanid can be decreased when combined with Nefazodone. DelamanidDitiocarb The metabolism of Delamanid can be decreased when combined with Ditiocarb. DelamanidTelaprevir The metabolism of Delamanid can be decreased when combined with Telaprevir.