Bioavailability and pharmacokinetics of natural volatile terpenes in animals and humans.

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Citation

Kohlert C, van Rensen I, Marz R, Schindler G, Graefe EU, Veit M

Bioavailability and pharmacokinetics of natural volatile terpenes in animals and humans.

Planta Med. 2000 Aug;66(6):495-505. doi: 10.1055/s-2000-8616.

PubMed ID
10985073 [ View in PubMed
]
Abstract

Herbal medicinal products containing natural volatiles are used in the treatment of gastrointestinal diseases, pain, colds and bronchitis. Many pharmacological studies report a wide variety of in vitro effects, with anti-inflammatory and antimicrobial activities investigated most frequently. In comparison, relatively few studies on the bioavailability and pharmacokinetics have been carried out. Thus, the relevance of the in vitro activity to the therapeutic effects found in individual studies or documented in textbooks of phytotherapy is still not established. Further studies with essential oils and their single compounds providing supporting evidence of efficacy and demonstrating systemic availability are necessary. Such data could also be important in the context of safety.

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