Vitamin B12 transporters.

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Russell-Jones GJ, Alpers DH

Vitamin B12 transporters.

Pharm Biotechnol. 1999;12:493-520.

PubMed ID

10742986 [ View in PubMed

]

Abstract

The uptake of vitamin B12 from the intestine into the circulation is perhaps the most complex uptake mechanism of all the vitamins, involving no less than five separate VB12-binding molecules, receptors and transporters. Each molecule involved in uptake has a separate affinity and specificity for VB12 as well as a separate cell receptor. Thus VB12 is initially bound by haptocorrin in the stomach, then by IF in the small intestine. An IF receptor is then involved in uptake of the IF-VB12 complex by the intestinal epithelial cell, with the subsequent proteolytic release of VB12 and subsequent binding to TcII. The TcII receptor then transports the TcII-VB12 complex across the cell, whence it is released into the circulation. It is surprising, then, that despite its complexity, it has been possible to harness the vitamin VB12 uptake mechanism to enhance the oral uptake of peptides, proteins, and nanoparticles.

DrugBank Data that Cites this Article

Drugs

Cyanocobalamin

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Cyanocobalamin	Transcobalamin-1	Protein	Humans	Unknown	Substrate	Details