Herpes simplex virus: receptors and ligands for cell entry.

Article Details

Citation

Copy to clipboard

Spear PG

Herpes simplex virus: receptors and ligands for cell entry.

Cell Microbiol. 2004 May;6(5):401-10. doi: 10.1111/j.1462-5822.2004.00389.x.

PubMed ID

15056211 [ View in PubMed

]

Abstract

Entry of herpes simplex virus (HSV) into cells depends upon multiple cell surface receptors and multiple proteins on the surface of the virion. The cell surface receptors include heparan sulphate chains on cell surface proteoglycans, a member of the tumor necrosis factor (TNF) receptor family and two members of the immunoglobulin superfamily related to the poliovirus receptor. The HSV ligands for these receptors are the envelope glycoproteins gB and gC for heparan sulphate and gD for the protein receptors and specific sites in heparan sulphate generated by certain 3-O-sulfotransferases. HSV gC also binds to the C3b component of complement and can block complement-mediated neutralization of virus. The purposes of this review are to summarize available information about these cell surface receptors and the viral ligands, gC and gD, and to discuss roles of these viral glycoproteins in immune evasion and cellular responses as well as in viral entry.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Talimogene laherparepvec	Heparan sulfate	Small molecule	Humans	Yes	Not Available	Details