Magnesium in Prevention and Therapy.

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Grober U, Schmidt J, Kisters K

Magnesium in Prevention and Therapy.

Nutrients. 2015 Sep 23;7(9):8199-226. doi: 10.3390/nu7095388.

PubMed ID

26404370 [ View in PubMed

]

Abstract

Magnesium is the fourth most abundant mineral in the body. It has been recognized as a cofactor for more than 300 enzymatic reactions, where it is crucial for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction. Imbalances in magnesium status-primarily hypomagnesemia as it is seen more common than hypermagnesemia-might result in unwanted neuromuscular, cardiac or nervous disorders. Based on magnesium's many functions within the human body, it plays an important role in prevention and treatment of many diseases. Low levels of magnesium have been associated with a number of chronic diseases, such as Alzheimer's disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and attention deficit hyperactivity disorder (ADHD).

DrugBank Data that Cites this Article

Drugs

Magnesium gluconate

Magnesium

Drug Interactions

Drugs	Interaction
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Alendronic acid Magnesium	Magnesium can cause a decrease in the absorption of Alendronic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amlodipine Magnesium	Magnesium can cause a decrease in the absorption of Amlodipine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bepridil Magnesium	Magnesium can cause a decrease in the absorption of Bepridil resulting in a reduced serum concentration and potentially a decrease in efficacy.
Besifloxacin Magnesium	Magnesium can cause a decrease in the absorption of Besifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bioallethrin Magnesium	Magnesium can cause a decrease in the absorption of Bioallethrin resulting in a reduced serum concentration and potentially a decrease in efficacy.