[Results of a study of the resorption of bufexamac following rectal administration].

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Glowania HJ, Hampl B

[Results of a study of the resorption of bufexamac following rectal administration].

Z Hautkr. 1988 Mar 21;63(3):211.

PubMed ID
3388925 [ View in PubMed
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Abstract

12 patients suffering from hemorrhoidal complaints were treated with hemorrhoidal suppositories containing Proctoparf-bufexamac. Using the HPCL method, we measured the concentrations of bufexamac in the serum after 30, 45 and 60 minutes as well as after 2, 3, 6, 7.5 and 20 hours. Neither bufexamac nor its major metabolite (4-butoxyphenyl acetic acid) could be detected in concentrations above 0.2 micrograms/ml and 0.5 micrograms/ml, respectively. These results prove that the application of Proctoparf suppositories is not associated with any significant systemic absorption of bufexamac.

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