Effect of arbutin on melanogenic proteins in human melanocytes.
Article Details
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Chakraborty AK, Funasaka Y, Komoto M, Ichihashi M
Effect of arbutin on melanogenic proteins in human melanocytes.
Pigment Cell Res. 1998 Aug;11(4):206-12.
- PubMed ID
- 9711535 [ View in PubMed]
- Abstract
The inhibitory effect of arbutin, a naturally occurring beta-D-glucopyranoside derivative of hydroquinone, on melanogenesis was studied biochemically by using human melanocytes in culture. Cells were cultured in the presence of different concentrations of arbutin. The maximum concentration of arbutin that was not inhibitory to growth of the cells was 100 micrograms/ml. At that concentration, melanin synthesis was inhibited significantly by approximately 20% after 5 days, compared with untreated cells. This phenotypic change was associated with the inhibition of tyrosinase and DHICA polymerase activities, and the degree of inhibition was dose dependent. No significant difference in DOPAchrome tautomerase (DT) activity was observed before or after arbutin treatment. Western blotting experiments revealed there were no changes in protein content or in molecular size of tyrosinase, TRP-1 or TRP-2, indicating that inhibition of tyrosinase activity by arbutin might be due to effects at the post-translational level.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Arbutin Tyrosinase Protein Humans YesInhibitorDetails