Salicylate intoxication: a clinical review.

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Pearlman BL, Gambhir R

Salicylate intoxication: a clinical review.

Postgrad Med. 2009 Jul;121(4):162-8. doi: 10.3810/pgm.2009.07.2041.

PubMed ID

19641282 [ View in PubMed

]

Abstract

Salicylates are widely used and are easily available as over-the-counter medications; thus, they can be readily abused. Although acute toxicity can be readily diagnosed if an ingestion history is provided, both acute and chronic salicylate toxicity often goes unrecognized, with high mortality when the patient is not treated properly. Salicylates should be considered in the differential diagnosis of an adult patient with acid-base abnormalities of uncertain cause, especially when there are concurrent neurologic symptoms. Patients with salicylate toxicity are treated with alkaline diuresis and sometimes dialysis. The prognosis depends on prompt recognition and treatment. Delayed diagnosis results in increased morbidity and mortality, particularly in the elderly.

DrugBank Data that Cites this Article

Drugs

Glycol salicylate

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
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Acetylsalicylic acid Dorzolamide	The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Acetylsalicylic acid.
Aminosalicylic acid Dorzolamide	The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Aminosalicylic acid.
Balsalazide Dorzolamide	The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Balsalazide.
Bismuth subsalicylate Dorzolamide	The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Bismuth subsalicylate.
Choline salicylate Dorzolamide	The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Choline salicylate.