Involvement of serotonin in zimelidine-induced hyperglycemia in mice.
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Sugimoto Y, Inoue K, Yamada J
Involvement of serotonin in zimelidine-induced hyperglycemia in mice.
Biol Pharm Bull. 1999 Nov;22(11):1240-1.
- PubMed ID
- 10598036 [ View in PubMed]
- Abstract
Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-HT depleter p-chlorophenylalanine(pCPA) were examined. pCPA significantly reduced zimelidine-induced hyperglycemia. This suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-HT reuptake inhibition.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Zimelidine Sodium-dependent serotonin transporter Protein Humans UnknownNot Available Details