Involvement of serotonin in zimelidine-induced hyperglycemia in mice.

Article Details

Citation

Sugimoto Y, Inoue K, Yamada J

Involvement of serotonin in zimelidine-induced hyperglycemia in mice.

Biol Pharm Bull. 1999 Nov;22(11):1240-1.

PubMed ID
10598036 [ View in PubMed
]
Abstract

Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-HT depleter p-chlorophenylalanine(pCPA) were examined. pCPA significantly reduced zimelidine-induced hyperglycemia. This suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-HT reuptake inhibition.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ZimelidineSodium-dependent serotonin transporterProteinHumans
Unknown
Not AvailableDetails